"Baricitinib for Treating Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotype.

For both groups : At inclusion visit : * Verification of inclusion and non-inclusion criteria * Patient information and signature of consent form * Pregnancy test (urine ou blood) * Randomization * Clinical evaluation (cardiac frequency, saturation, tracheal secretions, PaO2/FiO2 ratio, body temperature, mechanical ventilation support) * Collection of respiratory fluid and blood for biobank * Liver function test (AST, ALT, bilirubin), blood white cells count and EKG * Treatment compliance * Concomitant medications (antimicrobial therapy and steriods) * Survival and EQ-5D-5L At visit 1 to visit 10 ( Day1- day10) * Clinical evaluation (cardiac frequency, saturation, tracheal secretions, PaO2/FiO2 ratio, body temperature, mechanical ventilation support) * Study drug administration (daily) * Collection of respiratory fluid and blood for biobank (day 3 and day 7) * Liver function test (AST, ALT, bilirubin), blood white cells count and EKG (Liver, day 3 and day 7) * Treatment compliance * Adverse event * Concomitant medications (antimicrobial therapy and steriods) At visit 11(Day 10-12 test-of-cure) : * Clinical evaluation (cardiac frequency, saturation, tracheal secretions, PaO2/FiO2 ratio, body temperature, mechanical ventilation support) * Collection of respiratory fluid and blood for biobank * Collection of the respiratory fluid for bacterial cure * Liver function test (AST, ALT, bilirubin), blood white cells count and EKG * Adverse event * Concomitant medications (antimicrobial therapy and steriods) At visit 12 : * Adverse event * Survival and EQ-5D-5L At visit 13 (month 3) and visit 14 (month 6) : * Query in NHI Database (SNDS) for consumption of Health resources (pharmaceuticals, consultations...) * Survival and EQ-5D-5L * Health -related quality of the life (SF-36), anxiety/depression (HADS), subjective well-being (SWLS) * Interview with a researcher in pshychology (20 patients and their relatives - only in France)