Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Derby
With
University of Exeter
University of Plymouth
University Hospitals of Derby and Burton NHS Foundation Trust
Aston University
Royal Devon and Exeter NHS Foundation Trust
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
≥18 years of age at the time of enrolment
Previously confirmed or suspected SARS-CoV-2 infection
Confirmed diagnosis of Long COVID by a Health Care Practitioner according to the \*definition provided by the World Health Organisation for persistent symptoms following a confirmed SARS-CoV-2 infection.
Willing and able to provide informed consent, complete the surveys, and complete all planned clinical assessments, and return for scheduled study visits.
Evidence of persistent symptom profile relative to pre-COVID-19 status as derived from patient reported outcome measures.
Lives within commutable distance of the relevant centre, at discretion of local Principal Investigator.
* WHO define Long COVID as the continuation or development of new symptoms 3 months after the initial SARS-CoV-2 infection, with these symptoms lasting for at least 2 months with no other explanation.
You may not be if
Treatment history of Remdesivir, molnupiravir, paxlovid and/or any other COVID-19 anti-viral medication (\<6 months).
A diagnosis of a compromised immune system or function from a Healthcare Professional.
Currently engaged in a physical rehabilitation programme or intervention aimed to improve Long COVID symptom profile and/or functional status.
Recognised as a 'severe risk' of experiencing post-exertional malaise following engagement in physical tasks. Determined using the Modified De Paul Symptom Questionnaire.
Lack of mental capacity to provide informed consent.
Unable to understand verbal English/have a hearing impairment that prevents adequate communication.\*
Participation in another clinical drugs trial within the last 6 months
Currently pregnant, breastfeeding or attempting to get pregnant (i.e., not using effective methods of contraception).
Currently taking medications known to have an interaction with Remdesivir (e.g., chloroquine phosphate or hydroxychloroquine) as defined by British National Formulary (BNF) information on the selection, prescribing, dispensing and administration of medicines: https://bnf.nice.org.uk/interactions/Remdesivir/
History of serious adverse reactions to anti-viral medication and intravenous infusions
History of Hepatic or Renal Impairment (eGFR (\<30ml/min) and LFTs ALT\>x5 ULN).
Exeter participants only: No recent/long standing history of CT (within 3 months)/ ongoing radiotherapy treatment. Risks of accumulative burden to be discussed as part of study involvement but it is at the discretion of participants.
\*Note:
English Comprehension: Potential participants who are unable to understand verbal English will not be eligible for this study. This is due to the necessity of telephone contact which is a key aspect of this study and the unavailability of validated questionnaires in languages other than English.
Hearing Impairment: Unfortunately, if the participant has a hearing impairment that prevents adequate communication on the telephone, they will not be able to take part in the study. This will be clearly stated in the participant information sheet.
Clareo Health | An Open-label, Clinical Feasibility Study of the Efficacy of Remdesivir for Long-COVID.
