Other neurological disorders that may interfere with motor function
Unhealed decubiti, persistent infections that may interfere with ability to perform test procedures
Significant cognitive or communication impairment (Mini-Mental State Examination (MMSE\<21)), which could impede the understanding of the purpose of procedures of the study
Botulinum toxin (Botox) treatments to the lower limb within the past 6 months
Pregnant women
Contraindications to transcranial magnetic stimulation (TMS) or ischemic conditioning (IC) (Listed below)
Previous adverse reaction to TMS
Skull abnormalities or fractures
Concussion within the last 6 months
Unexplained, recurring headaches
Implanted cardiac pacemaker
Metal implants in the head or face
History of seizures or epilepsy
Use of medications that could alter cortical excitability or increase risk of seizure (e.g., antidepressants, antipsychotics, anxiolytics, anticonvulsants)
Current pregnancy
History of thrombosis (i.e., blood clots) including venous thrombosis or deep vein thrombosis (DVT).
Blood clots in the leg, or any condition in which compression of the thigh or transient ischemia is contraindicated (i.e., open wounds in the leg, bruising, nerve damage, etc.)
Peripheral arterial grafts in the lower extremity
History of uncontrolled hypertension
History of peripheral vascular disease or hematological disease
