COPD (determined by ratio of forced expiratory volume in 1 second to forced vital capacity \[FEV1/FVC\] \<0.7)
Age \>= 40 years
You may not be if
Exacerbation of COPD in the 3 months prior to enrollment
Change in COPD therapy in the 3 weeks prior to enrollment
Requirement of \>6 LPM supplemental oxygen at rest
Requirement of \>10 LPM supplemental oxygen with exertion
Active/uncontrolled cardiovascular disease (e.g. hypertension with blood pressure \>150/100 despite antihypertensives; coronary artery disease with angina; left ventricular ejection fraction ≤40%; arrhythmia; pulmonic, mitral or aortic valvular abnormality greater than mild in severity; tricuspid regurgitation greater than moderate in severity)
Volume overload (jugular vascular distension or greater than trace peripheral edema)
World Health Organization Functional Class IV
Known pulmonary hypertension with mean pulmonary artery pressure \>45 mmHg
Untreated severe obstructive sleep apnea or obesity hypoventilation syndrome
Active malignancy (other than skin)
Medical conditions that limit exercise on an upright stationary bicycle (e.g. severe osteoarthritis, imbalance/gait instability, etc.)
Pregnancy
Body mass index \<18 or \>40
Hematocrit \<25% or \>55%
For invasive CPET, chronic anticoagulation that is unable to be held for the study visit
For invasive CPET, forced expiratory volume in 1 second of \<20%
Clareo Health | Phenotyping Resting and Exertional Right Ventricular Dysfunction Among Patients With Chronic Obstructive Pulmonary Disease
