A Study To Evaluate The Effect Of A Supratherapeutic Dose Of MK-8189 On The QTc Interval In Participants With Schizophrenia (MK-8189-019)

Exclusion Criteria

• •History of a primary DSM-5 axis I psychiatric diagnosis other than schizophrenia or schizoaffective disorder per the allowed DSM-5 criteria.
• •History of intellectual disability, borderline personality disorder, anxiety disorder, or organic brain syndrome.
• •History of neuroleptic malignant syndrome or moderate to severe tardive dyskinesia (TD).
• •History of seizure disorder beyond childhood or is receiving treatment with any anticonvulsant to prevent seizures.
• •History of cancer.
• •History or presence of sick sinus syndrome, atrioventricular (AV) block, myocardial infarction, pulmonary congestion, cardiac arrhythmia, prolonged QTc interval, or conduction abnormalities.
• •History of risk factors for Torsades de Pointes (e.g., heart failure/cardiomyopathy or family history of long QT syndrome).
• •History of frequent syncope, vasovagal episodes, or epileptic seizures.
• •Family history of sudden cardiac death.
• •Has a positive test(s) for hepatitis B surface antigen (HBsAg), hepatitis C antibodies or human immunodeficiency virus (HIV).
• •Had major surgery, donated, or lost 1 unit of blood within 4 weeks prior to the pre-study visit.