Efficacy of Ginger Muco-bioadhesive Gel in Management of Oral Lichen Planus With Immunohistochemical Analysis

Exclusion Criteria

• •History of drug induced lichenoid lesions.
• •Presence of systemic conditions as; serious active or recurrent infections, malignancy, diabetes mellitus, hypertension, or significant heart, liver, or renal diseases. Assessed using medical questionnaire guided by Cornell Medical Index (Pendleton et al., 2004).
• •Smoking.
• •Known hypersensitivity or severe adverse effects to the treatment drugs or to any ingredient of their preparation as mentioned in medical history.
• •Pregnancy or breast-feeding.
• •History of previous treatments potentially effective on OLP such as antimalarial agents, retinoids, corticosteroids or immunosuppressive drugs from less than 2 weeks for topical medications, and 4 weeks for systemic medications prior to starting the study (Swift et al., 2005).
• •Patients suffering from lichen planus skin lesions.
• •Loss of pliability or flexibility in the tissues involved by the oral lesions of lichen planus.
• •Histological signs of epithelial dysplasia or lichenoid lesions within the biopsied.
• •Refusing to participate in the study.
• •Vulnerable groups (handicapped, orphans and prisoners).