Age

Any age

Sex

FEMALE

Healthy volunteers

Not accepted

Patients treated with HIPEC with cisplatin.
Estimated survival \> 12 weeks
Age from 18 to 70 years
Bone marrow reserve was well functioning. Leukocytosis ≥ 3.0×10\^9/L, neutrophilic granulocyte ≥ 1.5 × 10\^9/L, platelet count ≥ 100 × 10\^9/L, and hemoglobin ≥ 80 g/L.
Organs work well. AST ≤ 2.5 × ULN, ALT ≤ 2.5 × upper limit of normal(ULN), total serum bilirubin ≤ 1.5 × ULN, and creatinine ≤ 1.5 × ULN
ECOG score 0-1
Patients voluntarily sign an informed consent form

Extensive abdominal adhesions
HIPEC with Cisplatin for other medical conditions in the last 5 years.
Receiving other drugs that cause kidney damage.
Simultaneous use of amifotin for other diseases.
Any situation of disease instability or potentially impact safety and adherence of patient.
Chronic or acute nephropathy of any degree or other serious medical complications.

Effect of Sodium Thiosulfate on Nephrotoxicity of Cisplatin Intraperitoneal Heat-perfusion Chemotherapy