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Keep this study
Lead
Mary Phillips, MD MD (Cantab)
In a small pilot study the investigators propose to demonstrate feasibility of using tFUS to target the ventral striatum (VS) in humans by examining VS target engagement by tFUS in healthy human volunteers using a reward processing task that reliably activates the VS.
Age
18–35
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
18-35 years of age
No psychiatric history
You may not be if
Not between 18-35 years of age
Has psychiatric history
History of head injury, neurological, pervasive developmental disorder (e.g. autism), systemic medical disease and treatment (medical records, participant report)
Mini-Mental State Examination (MMSE) score (cognitive state) \<24
Premorbid North American Adult Reading Test (NAART) intelligent quotient (IQ) estimate\<85
Visual disturbance: \<20/40 Snellen visual acuity
Left/mixed handedness (Annett criteria)
History of alcohol/substance use disorder (SUD) (all substances, including nicotine), and/or illicit substance use (except cannabis) over the last 6 months (Structured Clinical Interview for Diagnostic and Statistic Manual of Mental Disorders , 5th Edition (DSM-5) (SCID-5)). Urine tests on scan days will exclude current illicit substance use (except cannabis). Salivary alcohol tests on scan days will exclude intoxicated individuals
Magnetic resonance imaging (MRI) exclusion: metallic objects, e.g., surgical implants; claustrophobia; positive pregnancy test for females or self-report pregnancy
Unable to understand English
Individuals with a positive pregnancy test will be excluded from the study and not undergo a computerized tomography (CT) scan or MRI scan
Present or history of seizure disorder
Clareo Health | Examining the Impact of Transcranial Focused Ultrasound (tFUS) on Reward Neural Circuitry
