pBFS Guided rTMS Treating Mild Alzheimer's Disease(AD)

Exclusion Criteria

• •Patients who have other causes of cognitive decline apart from AD, including but not limited to vascular dementia, Parkinson's disease dementia, dementia with Lewy bodies, frontotemporal dementia, and dementia due to endocrine system lesions or deficiencies of folic acid, vitamin B12 or other causes.
• •Patients with significant focal lesions seen on MRI, including more than two infarct foci larger than 2 cm in diameter, infarct foci in key areas such as the thalamus, hippocampus, internal olfactory cortex, pars oligo-cortical, angular gyrus, cortical and other subcortical gray matter nuclei.
• •Patients with moderate to severe cerebral white matter degeneration ( Fazekas score of 3-6).
• •Patients unable to undergo TMS treatment or MRI scan due to metallic foreign bodies, implanted electronic devices, or claustrophobia.
• •Patients with a history of seizures or epilepsy syndrome, or seizures within the past 12 months.
• •Patients with acute cardiovascular and cerebrovascular events within the 3 months prior to screening.
• •Patients with severe cardiac, pulmonary, hepatic, renal, and other systemic diseases that cannot be controlled with conventional medications.
• •Patients with malignant tumors or a life expectancy of less than 1 year due to reasons other than AD.
• •History of alcohol or drug abuse.
• •Having received other TMS treatments within the past three months.
• •Having participated, or is currently participating in other clinical trial programs within the past three months.