The Efficacy of Potassium-competitive Acid Blocker in Patients With Laryngopharyngeal Reflux Disease

Exclusion Criteria

• •Viral or bacterial laryngopharyngitis at present
• •History of malignancy of head and neck region, esophagus and stomach
• •Previous radiotherapy or endotracheal intubation within three months
• •Previous anti-reflux surgery or gastroesophageal surgery
• •Diagnosis of depression, anxiety, panic, somatoform or other psychotic disorder
• •Taking anti-psychotics, anti-depressants or anti-anxiety drugs
• •Anti-reflux medication such as proton-pump inhibitors (within 4 weeks before screening), histamine receptor 2 blockers, antacids or prokinetics (within 2 weeks before screening)
• •Need for continuous therapy with non-steroidal anti-inflammatory drugs
• •Pregnant or breastfeeding women, as well as female patients who were not willing to use contraception for the duration of the clinical trial period
• •Abnormal laboratory test values at screening (blood urea nitrogen and serum creatine level \>1.5 upper limit of normal \[ULN\]; total bilirubin levels and serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma-glutamyl transferase \> 2 ULN) or
• •Any other conditions or disease that an investigator considered not appropriate for this study