Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Arizona
With
Arizona State University
Age
18–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Active firefighter (including emergency medical responder and all firefighter subgroups) with either a volunteer or career status
Individual plans to remain in active service with their current agency for the next 2 years (not planning to retire or resign)
18 years of age and older
Fluently speak and write in English
All sexes, races, and ethnicities
Enrolled in the Fire Fighter Cancer Cohort Study (FFCCS) prior to enrolling in the Firefighter Collaborative Research Project (FCRP)
Complete a signed and dated informed consent document that indicates the participant has been informed of all aspects of the study prior to enrollment
Agree to avoid participating in FCRP intervention activities outside of their assigned intervention group for the duration of the study
Able to comply with scheduled visits, laboratory tests and other study procedures
BMI of 17.5 kg/m2 or greater and be greater than 115 pounds
Must also be eligible to donate blood and blood-based products if randomized into the blood or plasmapheresis intervention groups
You may not be if
Not able to fluently speak or write in English
Less than 18 years of age
Currently a tobacco smoker or vaping (e.g. \>2 cigarettes or cigars, or incidents of vaping in the past month)
Those with planned travel or extended leave (e.g. \>6 weeks) that would prevent their ability to participate in other interventions
Those who are pregnant, breastfeeding, or have given birth within the past year
Those with a history or diagnosis of any significant metabolic, hematologic, pulmonary, cardiovascular, gastrointestinal, neurological, immune, hepatic, renal, urological disorders, severe injury or cancer that, in the opinion of the investigator, would potentially put the candidate at risk.
Those with PFOS levels \<5 ng/ml
Those with any medical contraindication (medical condition or medication) to blood donation
Those that donated blood or plasma in the past three months
Those knowing they have a condition indicative of levels of hemoglobin, hematocrit, red blood cells, or iron below the lower limit of normal levels
Those with a history or diagnosis of diabetes, hypoglycemia thyroid disease, and/or an eating disorder
Those who recently participated in intermittent fasting or Time Restricted Eating
Those that recently used antidiabetic medication such as Semaglutide (sold as Ozempic, Wegovy, and Rybelsus) or Tirzepatide (sold as Mounjaro) for the treatment of type 2 diabetes or for weight loss will also be excluded from this group.
Use of drugs that might affect intermittent fasting or eating behaviors
Those outside of the state of Arizona
Exclusion from the zone-2 physical activity intervention:
Currently participating in zone 2 physical activity training
Currently participating in more than 120 minutes per week of aerobic, cardiovascular training (e.g. jogging, cycling, walking, swimming, HIIT) at \>60% of their max heart rate.
Those outside of the state of Arizona or in cities in Arizona where access to CPET testing is not possible
