Implantation of iodine125-Seeds Combined With Chemotherapy in the Treatment of Metastatic Pancreatic Carcinoma

Inclusion Criteria

• •(Before the trial, subjects must meet all of the requirements listed below in order to be enrolled)
• •1. 18 to 80 years old;
• •2. Stage IV pancreatic ductal adenocarcinoma with distant metastases confirmed by clinical, imaging, and pathology, and the primary and metastatic mass can be measured on imaging.
• •3. No treatment history of chemotherapy, radiotherapy, or surgery
• •4. Expected survival \> 6 months
• •5. ECGO score of 0-2
• •6. Eligible for chemotherapy (white blood cell \> 3.5×109/L, neutrophil value \> 1.5×109/L, hemoglobin \> 80g/L, platelets \> 100×109/L, albumin \> 25g/L, alanine aminotransferase or aspartate aminotransferase ≤ 3 times the upper limit of normal and total bilirubin level ≤ 34.2umol/L, creatinine \< 176.8 umol/L, normal ECG)
• •7. Signed written informed consent;