Lead Sponsor

Istituto Ortopedico Rizzoli

Age

20 - 80 years

Sex

ALL

Healthy Volunteers

Yes

•Age: 65-80 years
•Body Mass Index between 18.5 and 30 kg/m2
•Frailty syndrome diagnosed according to Fried's criteria (i.e., at least three of the following items: unintended loss of weight, weakness, self-reported exhaustion, slow walking speed, low level of physical activity)
•Age: 20-40 years;
•Body Mass Index: 15-30 kg/m²;
•Physical activity level (Saltin-Grimby): 2-4
•No previous or known musculoskeletal, neurological, rheumatic or tumoral diseases

•Any musculoskeletal, neurological, rheumatic or tumoral diseases
•Dementia
•Diabetes
•Inguinal or abdominal hernia
•Severe Hypertension (Level 3)
•Severe Cardio-pulmonary insufficiency
•Diagnosis of Osteonecrosis in the lower limb joints
•Pathologies or physical conditions incompatible with the use of magnetic resonance imaging and electrostimulation (i.e., active and passive implanted biomedical devices, epilepsy, severe venous insufficiency in the lower limbs)
•Previous interventions or traumas to the joints of the lower limb
•NOTE: A group of healthy volunteers, who meet the following criteria, will be enrolled in the study: