Meet DSM-V criteria for a current depressive episode.
Being first-episode patients who were medication-naïve;
Score \>17 on 17-item Hamilton Depression Rating Scale (HDRS), score \>22 on Montgomery-Asberg Depression Rating Scale (MADRS), and score \<6 on Young Mania Rating Scale (YMRS).
Age 18 to 35.
Able to give written informed consent.
You may not be if
Have a current or past significant medical, neurological or metabolic disorder or head injury
Have active, significant suicidal ideation or past suicide attempts
Have implanted metallic devices or any MR contraindications
Are women who are pregnant or breastfeeding
Met DSM-5 criteria for substance use disorder
Met DSM-5 criteria for any current Axis I diagnosis (except Generalized Anxiety Disorder)
Are MDD patients present with delusions and/or hallucinations
Clareo Health | Using 18F-FPEB PET to Identify mGLUR5 Availability in Affective Disorders
