Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction

Inclusion Criteria

• •Diagnosis of Heart Failure, Left Ventricular Ejection Fraction (LVEF) ≥ 55% (this and other measurements must be made within the last year).
• •New York Heart Association (NYHA) Functional Class I-III
• •Stable on guideline-directed medical therapy (GDMT) heart failure medications as determined by the investigator, for at least 1 month, with the exception of loop diuretic therapy. GDMT should be in accordance with current American Heart Association (AHA)/American College of Cardiology (ACC)/Heart Failure Society of America (HFSA) Guidelines and include consideration of Sodium/glucose cotransporter-2 inhibitors (SGLT2i) therapy.
• •V End Diastolic Volume indexed to body surface area (BSA) ≤ 80 mL/m\^2.
• •Concentric remodeling or concentric hypertrophy defined as at least one of the following criteria:
• •* Left ventricular (LV) posterior or lateral wall thickness \> 11mm
• •* Relative wall thickness (RWT) \> 0.42
• •* Male and LV mass indexed to BSA ≥115 g/m2
• •* Male and LV mass indexed to height ≥ 49.2 g/m2.7
• •* Female and LV mass indexed to BSA ≥ 95 g/m2
• •* Female and LV mass indexed to height ≥ 46.7 g/m2.7