AHSCT With Fludarabine and Cyclophosphamide Based Conditioning Regimes in Patients With Multiple Sclerosis

Inclusion Criteria

• •Age 18-65;
• •1.0-6.5 points on the EDSS scale (for MS);
• •Length of illness - any;
• •Disease progression during the last 6 months while taking drugs of 1st and 2nd lines;
• •An established and confirmed diagnosis of an autoimmune disease in the previous stages of treatment;
• •Ineffectiveness, inaccessibility or intolerance of Disease-Modifying Therapies;
• •Relapse after AHSCT.
• •Absence of severe concomitant somatic pathology;
• •Left ventricular injection fraction \> 50%;
• •Karnofsky Performance Score (KPS) \> 30%;
• •The ability to take oral medications;
• •Life expectancy is more than 1 month;
• •Signed informed consent of the patient or legal representatives.