Microvascular Cardiac Allograft Vasculopathy Trial

Exclusion Criteria

• •Addiction or other diseases that do not allow the patient to assess the nature and scope as well as possible consequences of the study
• •Patients or their legal guardians who do not sign the declaration of consent or who cannot fully understand it due to a lack of German language skills
• •Pregnant women, breastfeeding women
• •Severe comorbidities affecting the miRNA profile: diabetes mellitus, malignancy, end-stage renal disease with renal replacement therapy
• •Contraindication to the stress test: signs of cardiac decompensation, angina pectoris, dyspnea, hyperthyroidism, GFR \<30 ml/min, peripheral arterial disease, pheochromocytoma, angle-closure glaucoma, prostate adenoma, paroxysmal tachycardia, tachycardia atrial fibrillation
• •Evidence of an acute rejection or local wall motion disturbances in the resting echocardiography