Low Dose IL2 Immunotherapy in AD

Exclusion Criteria

• •Serious, active bacterial, fungal or viral infection
• •Severe pulmonary dysfunction. FEV1 and FVC less than 40% of predicted (or 3 SD below normal) at baseline, If a pulmonary function test is clinically indicated. Hx of intubation for \>72 hours.
• •Severe cardiac dysfunction defined as left ventricular ejection fraction \<40% if an echocardiogram is medically indicated to clarify ongoing symptoms or EKG findings.; a history of non-controlled cardiac arrhythmias; history of cardiac tamponade; Unstable angina or MI in the last 3 months
• •Hypersensitivity or allergy to IL-2
• •Bowel ischemia/perforation, GI bleeding requiring surgery
• •Resistant seizures, history of coma or toxic psychosis lasting \>48 hours
• •Patients with White Blood Count (WBC) \<4,000/mm3; platelets \<100,000/mm3; hematocrit (HCT) \<30%.