Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Change in Cardiovascular Health

Exclusion Criteria

• •Participant with a history of cardiovascular disease, defined by a diagnosis of coronary artery disease, peripheral artery disease, or cerebrovascular disease
• •Participant with quantifiable plaque on a coronary computed tomography angiography
• •Participant with a history of Liver disease (cirrhosis, active hepatitis, or severe hepatic disease) or any of the following recent lab results and determined to be non-transient: alanine aminotransferase greater than 3 times the upper limit of normal or total bilirubin greater than 2 times the upper limit of normal (unless due to Gilbert syndrome)
• •Participant with estimated glomerular filtration rate \<60 mL/min/1.73 m2 or creatinine greater than 2 times the upper limit of normal
• •Patient with history of an allergic reaction or significant sensitivity to iodinated contrast, colchicine, or statins
• •Patient currently taking LDL cholesterol lowering or anti- inflammatory medications including colchicine
• •Participants requiring regular drugs known to be potent CY2P inhibitors (eg. ketoconazole, clarithromycin)
• •Female patient who is pregnant, or breast-feeding or is considering becoming pregnant during the study
• •Participant with BMI ≥ 40 kg/m2
• •Participant unable to provide informed consent
• •Participant unable to hold breath for 10 seconds