Amantadine and Transcranial Magnetic Stimulation for Treating Fatigue in Multiple Sclerosis

Exclusion Criteria

• •1. Fatigue causing disease other than multiple sclerosis:
• •1. sleep apnea
• •2. other autoimmune disease that could be explain the fatigue.
• •3. endocrine autoimmune disease if the blood test is not in range in the last 6 month.
• •4. patient with diagnosis of chronic fatigue
• •5. Patient with high blood pressure out of range or decompensated heart failure or New York Heart Association (NYHA) 3-4.
• •2. Secondary Epilepsy or neuropathic chronic pain which requires continuous treatment.
• •3. Contraindication for trial treatment:
• •1. Some kind of magnetic metal.
• •2. Epilepsy antecedents.
• •3. Any drugs that could decrease the seizure threshold
• •4. Amantadine sensitivity
• •5. Cardiopathy disease, severe kidney failure, Angle-closure glaucoma
• •4. Breastfeeding, pregnancy, or pregnancy planning phase in the next year. Of childbearing potential and willing to use an acceptable method of contraception during the study period.
• •5. Patient with a terminal disease with no more than one year life expectancy.
• •6. Patient has been treated for a maligned disease in the past three years.
• •7. A scheduled surgery in the course of the trials.
• •8. Any condition that a member of research team consider could affect to participation/follow up patient.
• •9. Alcoholic o toxics condition in the last year.
• •10. Major mental disorders
• •11. Poor communication skills or poor cognitive condition.
• •12. Other trial participation in the previous 4 month.
• •13. Use a chronic drug that could interfere in the clinical outcome.