Combination of Chidamide and Fulvestrant for HR+/HER2- Breast Cancer That Has Failed Previous CDK4/6 i Adjuvant Therapy

Exclusion Criteria

• •1. Prior treatment with any HDAC inhibitors;
• •2. Known allergy to the tested drug component;
• •3. inflammatory breast cancer at the time of screening;
• •4. pia meningeal metastasis confirmed by MRI or lumbar puncture;
• •5. Central nervous system metastasis confirmed by imaging;
• •6. To the best of the investigator's judgment, symptomatic visceral disease or any disease load or none is considered optimal Endocrine therapy options are not suitable for endocrine therapy;
• •7. Inability or unwillingness to swallow medication or receive intramuscular injections;
• •8. Gastrointestinal insufficiency or gastrointestinal disease (if not controlled) that may significantly affect study drug absorption Ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or small intestine resection, etc.;
• •9. Patients with ascites, pleural effusion and pericardial effusion accompanied by clinical symptoms in the baseline period need drainage, or use it for the first time Patients with serous cavity drainage within 4 weeks before medication;
• •10. A history of immunodeficiency, including HIV positive, or other acquired or congenital immunodeficiency conditions, Or have a history of organ transplantation;
• •11. Other malignancies (cured basal cell carcinoma of the skin, carcinoma in situ of the cervix, and Thyroid cancer is excluded);
• •12. had undergone major surgical procedures or significant trauma within 4 weeks prior to the start of treatment, or was expected to undergo major surgery Surgical treatment;
• •13. Concomitant diseases that, in the investigator's judgment, seriously endanger patient safety or interfere with patient completion of the study (e.g.
• •Severe hypertension, diabetes, thyroid disease, co-active hepatitis B/C, and other activities Sexual infection);
• •14. Inability to understand or follow research instructions and requirements;
• •15. The researcher decides that it is not suitable to participate in this study