Non-metastatic pancreatic adenocarcinoma that is not immediately resectable (borderline and locally advanced tumors according to the NCCN 2020 classification)
No previous treatment with surgery or chemotherapy
Age \> 18 years
General condition WHO 0-2 (patient whose general condition can allow medical treatment or surgery)
Therapeutic management at the Paoli-Calmettes Institute
Signature of the informed consent specific to the PANDORE-PANC study
Patient affiliated to a social security system or benefiting from such a system
You may not be if
Metastatic disease
Pancreatic tumor of a histological type other than adenocarcinoma
Other tumor under treatment or for which treatments have been completed for \< 1 year
Pregnant or breastfeeding women
Person in an emergency situation
Person of legal age under legal protection (guardianship, curatorship or safeguard of justice) or unable to give consent.
