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Effect of Ketamine Infusion on BIS Values | Clinical Trials | Clareo Health

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Effect of Ketamine Infusion on BIS Values

Correlation Between Concentration at the Effector Site of Continuous Infusion of Ketamine (Calculated With DOMINO Pump) and Bispectral Index Values During General Anaesthesia for Breast Surgery

NCT05799729•University of Padova

View on ClinicalTrials.gov

Summary

Aim of this trial is to define if Concentration at the effector site (Ce) of Ketamine, during a continuous infusion and calculated with DOMINO model infusion pump are correlated with Bispectral Index BIS values during general anaesthesia for breast surgery.

Detailed Description

Correlation between Concentration at the effector site (Ce) of Ketamine and Bispectral Index (BIS) values during general anaesthesia for breast surgery has not been defined yet during a continuous infusion. Authors want to analyze this correlation during general anaesthesia conducted using Propofol, ketamine and remifentanil. All of these drugs will be delivered with Target-Controlled Infusion pumps (in particular Eleveld for Propofol, Minto for Remifentanil and Domino for Ketamine). Ketamine will be observationally set at anaesthesiologist's discretion, but only CeK 0.1, 0.2, 0.4 and 0.6 for at least 30 minutes will be considered for analysis.

Eligibility

Age

18 - 90 years

Sex

FEMALE

Healthy Volunteers

Inclusion Criteria

•Undergo general anaesthesia with Targeted Controlled Infusion of Ketamine (Domino model), Propofol (Schnider model) and Remifentanil (Minto model)

Exclusion Criteria

•Neurological disease
•Psychiatric disease
•Benzodiazepines intake
•Obesity

Locations (1)

Treviso Regional Hospital

Treviso, TV, Italy

Key Dates

Start Date

April 1, 2023

Primary Completion Date

September 30, 2023

Completion Date

September 30, 2023

Last Updated

October 19, 2023

Enrollment

ACTUAL participants

Conditions

Anesthesia Brain MonitoringKetamine

Interventions

Ketamine

DRUG

Premedication in Children: a Clinical Trial Comparing Oral Ketamine and Oral Clonidine With Respect to Sedation Level and Opioid Consumption in Pediatrics Undergoing Elective Lower Abdominal Day-case Surgery.

NCT07461376

Pediatric SedationClonidine Sedation+1 more

View study

RECRUITING

Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients

NCT07222007

Critically IllIntubation Complication+4 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 19, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Effect of Ketamine Infusion on BIS Values

Inclusion Criteria

Exclusion Criteria

Premedication in Children: a Clinical Trial Comparing Oral Ketamine and Oral Clonidine With Respect to Sedation Level and Opioid Consumption in Pediatrics Undergoing Elective Lower Abdominal Day-case Surgery.

Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients

Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study

Minto and Eleveld Remifentanil Target Controlled Infusion (TCI) Models: a Clinical Comparison

Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia

Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery