Ultrasound Ablation for Essential Hypertension（FIM）

Exclusion Criteria

• •1. Ineligible renal artery anatomy including : (1) multiple renal arteries, (2) main renal artery diameter \<4mm or length \<20mm, (3) renal artery stenosis \> 50% in the main renal artery, (4) atherosclerosis of the renal artery, renal artery aneurysm, fibromuscular dysplasia or calcification, (5) pre-existing renal stent, (6) single kidney
• •2. Estimated glomerular filtration rate (eGFR) \<45 mL/min/1.73 m2
• •3. Type Ⅰ diabetes mellitus or poorly controlled type Ⅱ diabetes mellitus (defined as plasma Hb1Ac≥ 9.0% or 24-hour urinary protein quantification \>1g/24h or proliferative retinopathy)
• •4. Postural hypotension
• •5. Recent vascular events: Experienced acute myocardial infarction, unstable angina, syncope, or cerebrovascular accident within 3 months of the screening period
• •6. Possible secondary hypertension
• •7. Respiratory support: The individual requires long-term oxygen support or mechanical ventilation other than nocturnal respiratory support for sleep apnea
• •8. Life expectancy \<1 year
• •9. Female who is pregnant, nursing, or planning to become pregnant
• •10. Subjects who are currently enrolled in another clinical trial and have not completed their primary endpoint
• •11. Subjects who are allergic to contrast medium
• •12. Subjects who are unsuitable for the trial ，because of poor patient compliance or other reasons judged by the investigator