Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Texas Southwestern Medical Center
Objective:
To determine the incidence of postoperative urinary retention after reversal of rocuronium-induced neuromuscular blockade by neostigmine versus sugammadex in patients undergoing laparoscopic cholecystectomy.
Hypothesis:
Subjects who are reversed with sugammadex will have less postoperative urinary retention compared to subjects who are reversed with neostigmine.
Age
18–80
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
18-80 years old
Undergoing laparoscopic cholecystectomy
Anticipated surgical duration \<2 hours
ASA physical status classification 1-3
Willing and able to consent in English or Spanish
No personal history of neuromuscular disease
You may not be if
Preoperative urinary catheter
History of problems with urination
Current use of anticholinergic medications (e.g., antihistamines, phenothiazines, antidepressants, antipsychotics)
Current UTI or urogenital problem (incontinence, known bladder retention, prostate hypertrophy)
Planned intraoperative insertion of a urinary catheter
ESRD (GRF \<30 mL/min)
ESLD (AST or ALT \> 3x reference range)
Planned postoperative intubation/ventilation or admission to ICU
Allergy to sugammadex, neostigmine, glycopyrrolate, or rocuronium
Pregnant or nursing women
"Stat" (emergent) cases
Known or suspected neurological condition (e.g., Alzheimer's, h/o of stroke, multiple sclerosis, Parkinson's)
Patients on toremifene (a selective estrogen receptor modulator)
Women on oral contraceptives who do not wish to use a non-hormonal method of contraception for 7 days following surgery
