The Intervention of Obesity in Children With Prader-Willi Syndrome Using Prebiotics and Probiotics

Exclusion Criteria

• •Losing weight in ways other than the intervention measures of this project, such as taking weight loss drugs or known drugs that cause weight change;
• •Use antibiotics within 1 month before the study and lasted for 3 days or more;
• •Use probiotics within 1 month before the study and lasted for 3 days or more;
• •Complicated with liver and renal insufficiency (alanine aminotransferase and serum creatinine indexes exceed 2 times the upper limit of the normal value set by the hospital);
• •Have gastrointestinal diseases affecting food digestion and absorption (such as severe diarrhea, constipation, severe gastrointestinal inflammation, active gastrointestinal ulcer, acute cholecystitis, etc.); severe diarrhea refers to watery stool 3 or more times a day and lasts for 3 or more days. severe constipation refers to defecation 2 or less times a week with difficulty in defecation;
• •Surgery was performed within 1 year before the study (except for appendicitis and hernia surgery);
• •Have hepatitis B, active tuberculosis, AIDS and other infectious diseases;
• •Those who are suffering from mental illness and are taking psychotropic drugs such as antidepressants.