The Effect of Colchicine on Food-related Effort-based Decision Making in Brain and Behaviour in Overweight and Obesity

Exclusion Criteria

• •Having been vaccinated by any type of vaccine in the 4 weeks preceding the first test session
• •Having had an infection characterized by a fever, or diagnosed by a medical physician in the 4 weeks preceding the first test session
• •Diagnosed with Diabetes Mellitus type I or II
• •Gained or lost \>2 points in BMI (kg/m2) over the last 6 months
• •Followed an energy restricting diet during the last 2 months
• •Having had bariatric surgery in the past 5 years
• •Regular use of anti-inflammatory, anti-diabetic, weight-loss, and psychoactive medication
• •Regular use of CYP3A4 inhibitors, P-glycoprotein inhibitors, statins, fibrates, ciclosporin, and digoxin, as a contraindication for colchicine
• •Have renal impairment as evidenced by serum creatinine \>150 μmol/l or eGFR \<50mL/min/1.73m2, determined maximum 12 weeks before inclusion
• •Have moderate to severe hepatic disease
• •(History of) clinically significant psychiatric or neurological disorder
• •(History of) clinically significant metabolic, cardiovascular, renal, liver, endocrinological, autoimmune or chronic inflammatory disease
• •General medical conditions, such as sensorimotor handicaps, deafness, blindness or colour-blindness, as judged by the investigator
• •Current or history of alcohol and/or drugs abuse (i.e. \>14 units per week)
• •Habitual smoking, i.e. one or more cigarettes per day
• •Pregnant, lactating or wishing to become pregnant in the period between the screening and until 3 months after the last study visit
• •Participation in another weight loss, lifestyle or anti-inflammatory intervention in the context of research at the time of inclusion or during the study
• •Contraindications for MRI