A Multicomponent Intervention Program to Prevent and Reduce ICU Agitation and Physical Restraint Use

Exclusion Criteria

• •Contra indication for dexmedetomidine use (i.e., AV-block grade 2 or 3 unless a pacemaker is present, uncontrolled hypotension, acute cerebrovascular condition or known/suspected hypersensitivity);
• •Neurological patients with an (expected risk of) increased intracranial pressure;
• •An intoxication as a result of drug abuse (e.g., ethanol, γ-Hydroxybutyrate, opioids, benzodiazepines);
• •Support with Extracorporeal Membrane Oxygenation (ECMO);
• •Difficult airway (e.g., a Cormack and Lehane laryngoscopy grade 4 view or a tumor causing airway obstruction);
• •A high risk of physical aggression towards healthcare professionals;
• •No consent for long term follow up in the MONITOR-IC study;
• •Not able to read or understand the Dutch language and no relatives able to assist;
• •Enrolment in other sedation studies.