1. End-stage stage renal disease on dialysis or eGFR \<20 mL/kg/1.73m2.

2. Pre-menopausal woman who are either breast-feeding or pregnant

3. History of heart transplant or actively listed for heart transplant

4. Implanted left ventricular assist device or implant anticipated within 3 months.

5. Enrolled in or planning to enroll in hospice care.

6. Active cancer (except localized prostate, breast, or non-melanoma skin cancers)

Optimizing In-hospital Use of Evidence-based Therapies for Patients With Cardio-Renal-Metabolic Disease