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Multicentre Randomised Study Comparing a Taurolidine Lock and a Standard Saline Lock in Paediatric Oncology | Clinical Trials | Clareo Health

RECRUITINGNA

Multicentre Randomised Study Comparing a Taurolidine Lock and a Standard Saline Lock in Paediatric Oncology

Multicentre Randomised Study Comparing a Taurolidine Lock and a Standard Saline Lock in the Primary Prevention of Catheter-related Endoluminal Infection in Paediatric Oncology.

NCT05781295•Institut Curie

View on ClinicalTrials.gov

Summary

Interest of a Taurolidine lock at each catheter closure in the primary prevention of catheter-related endoluminal infection in paediatric oncology. Multicentric, controlled, randomized and double-blind label study.

Detailed Description

The patient will be followed according to the type of pathology and the respective treatment protocol either Taurolock or physiological serum at each time cathter will be used.

Eligibility

Age

0 - 21 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Patient less than or equal to 21 years of age at inclusion.
•2. Patient for whom a central catheter is planned to be inserted\*, excluding a non-tunneled femoral or cervical external catheter or a peripherally inserted central catheter (as PICC line). \*1st catheter placement or placement following a relapse (this placement must take place at least one month after previous catheter removal).
•3. Patient treated for a cancer.
•4. Patient with regular follow-up in the inclusion center.
•5. Informed consent signed by the patient if adult or by legal representatives if minor.
•6. Patient benefiting from a social security coverage.
•7. Time between the date of catheter placement and the planned date for the first solution lock injection less than 6 weeks.

Exclusion Criteria

•1. Patient with retinoblastoma.
•2. Allografted patient.
•3. Patient with a life expectancy of less than 6 months.
•4. Patient refusing to participate in the protocol.
•5. Patient already receiving a central venous catheter-related infection prevention lock (ILCVC).
•6. Patient with known allergy to citrate or (cyclo)-Taurolidine.
•7. Patient taking other drugs with a known contraindication with citrate or (cyclo)-Taurolidine.
•8. Patient with an external femoral catheter.
•9. Patient with a PICCLINE-type peripheral venous inserted central catheter.
•10. Patient unable to submit to the medical follow-up of the trial for geographical, social or psychological reasons.
+1 more criteria

Locations (5)

Institut Curie

Paris, France

Saint Louis

Paris, France

Armand Trousseau

Paris, France

Robert Debre

Paris, France

Gustave Roussy

Villejuif, France

Key Dates

Start Date

January 19, 2024

Primary Completion Date

July 23, 2028

Completion Date

July 23, 2028

Last Updated

February 20, 2026

Enrollment

148

ESTIMATED participants

Conditions

ChildrenMedical DevicePrimary PreventionOncology

Interventions

TaurolockTM

DEVICE

Physiological serum

DEVICE

Contacts

Camille CORDERO, MD

CONTACT

+33172389309 camille.cordero@curie.fr

Marie-Emmanuelle Legrier, PhD

CONTACT

drci.promotion@curie.fr

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 20, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Multicentre Randomised Study Comparing a Taurolidine Lock and a Standard Saline Lock in Paediatric Oncology

Inclusion Criteria

Exclusion Criteria

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