An Observational Study of Patients With Moderate Parkinson's Disease

Exclusion Criteria

• •Any atypical or secondary Parkinson's disease, or non-Parkinson's disease-suspected cause(s) of, or contributors to, parkinsonism, as judged by the investigator.
• •Significant drug-induced dyskinesias as judged by the investigator, e.g., as defined by a score of \> 2 in the Abnormal Involuntary Movement Scale (AIMS), in any body part in the ON state.
• •Tremor-dominant Parkinson's disease, as judged by the investigator.
• •Cognitive impairment predictive of dementia (including Parkinson's disease dementia) or other cognitive dysfunction as judged by the investigator, e.g., as defined by Montreal Cognitive Assessment (MoCA) score ≤ 24, or evidence of major neurocognitive disorder according to the Diagnostic and Statistical Manual of Mental Disorders V (DSM-V) criteria.
• •Major medical or psychiatric disorder (e.g., depression (Montgomery-Asberg Depression Rating Scale (MADRS) \>20) or psychosis), or other disease making the patient unsuited for participation in the study, as judged by the investigator.
• •Treatment for dystonia or spasticity within 3 months of screening (Botox for a focal dystonia is allowed).
• •Substantial neurological symptoms not accounted for by Parkinson's disease, including active seizure disorder, as judged by the investigator.