Gamma Light and Sound Stimulation to Prevent Dementia in Cognitively Normal People At Risk for Alzheimer's Disease

Exclusion Criteria

• •1. MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body.
• •2. High myopia \< -7 diopters, or untreated cataracts that affect vision.
• •3. Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the study protocol.
• •4. For subjects agreeing to undergo lumbar punctures, history of bleeding disorders or laboratory results indicating low platelet levels are exclusionary for the procedure.
• •5. Concomitant medications:
• •1. Treatment with NMDA antagonists.
• •2. For subjects undergoing lumbar puncture, current use of warfarin or similar anti-coagulants is exclusionary for the procedure.
• •6. Clinical conditions:
• •1. History of seizure or medical diagnosis of epilepsy.
• •2. Female subjects who are pregnant or currently breastfeeding.
• •3. History of severe allergic or anaphylactic reactions.
• •4. Longstanding premorbid history (i.e., longer than 10 years) of alcohol or substance abuse with continuous abuse up to and including the time that the symptoms leading to clinical presentation developed.
• •5. Neurodegenerative disorder associated with cognitive impairment.
• •6. Renal disease.
• •7. MR imaging findings such as stroke, tumor, leukoencephalopathy that could preclude meaningful analyses of clinical and imaging data in the opinion of the site PI, such as:
• •1. Severe leukoencephalopathy seen on MRI.
• •2. Relevant structural abnormality (i.e., normal pressure or obstructive hydrocephalus, hypoxic ischemic lesions, hemorrhages, tumors, malformations).
• •3. Cerebral amyloid angiopathy, evidenced by T2\* or other susceptibility weighted-MRI.
• •8. Laboratory findings, if known (study does not perform testing) suggestive of systemic illness such as renal disease.
• •9. Site investigator's discretion, if s/he feels the subject cannot complete sufficient key study procedures. Exceptions to these guidelines may be considered on a case-by-case basis at the discretion of the Project Director.