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Protein Turnover in Healthy and Overuse-diseased Tendon | Clinical Trials | Clareo Health

COMPLETEDNA

Protein Turnover in Healthy and Overuse-diseased Tendon

NCT05776485•Bispebjerg Hospital

Summary

The goal of this clinical trial is to examine the regional protein turnover in tendon tissue from patients with chronic patellar tendinopathy and comparing this to healthy controls. Further we will examine the effect of resistance training on protein turnover in healthy individuals.

Eligibility

Age

18 - 40 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Physical active men and women
•Body mass index 18,5 - 30 kg/m2
•Debut of symptom \> 90 days prior to inclusion.
•Subjective activity related pain in patella tendon.
•Clinical symptoms of patella tendinopathy.
•Ultrasound verification of at least 1 in three of the following: Enchanced anterior-posterior diameter, increased Doppler signal and/or a hypoechoic area in the diseased part of the tendon.

Exclusion Criteria

•Former knee surgery or injuries to the patella tendon.
•Local injection of corticosteroids within 12 months.
•Medication that affects protein synthesis in tendon tissue.
•Former/current use of anabolic steroids or growth hormone.
•Smoking
•Known rheumatoid disease or diabetes.
•Former participation in trials using deuterated water and 15N tracers.
•Treatment for patella tendinopathy within 3 months.

Locations (1)

Institute of Sports Medicine Copenhagen

Copenhagen, Capital Region, Denmark

Key Dates

Start Date

May 10, 2023

Primary Completion Date

May 1, 2024

Completion Date

May 1, 2024

Last Updated

June 3, 2024

Enrollment

ACTUAL participants

Conditions

Patella; Tendinitis

Interventions

Progressive resistance training

OTHER

Cross-sectional comparison between healthy and tendinopathic group

OTHER

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Patellar TendinitisPatella; Tendinitis+1 more

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UNKNOWN

Identification of Early Changes in Patellar Tendinopathy Using Ultra-high Field Strength MRI

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Tendon InjuriesTendinopathy+1 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 3, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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