PaCO2\>8.0 kPa, or PaO2\<6.0 kPa

6-minute walk test\<160m

Obvious chronic bronchitis, bronchiectasis or other infectious pulmonary diseases

More than 3 hospitalizations for pulmonary infection in the past 12 months before baseline assessment

Previous lobectomy, LVRS or lung transplantation

LVEF\<45% and or RVSP\>50mmHg

Anticoagulant therapy that cannot be stopped before surgery

Patients with obvious immune deficiency

Participated in other lung drug studies within the first 30 days of this study

Pulmonary nodules requiring intervention

Any disease or condition that interferes with the completion of the initial or subsequent assessment

Long-term Effects of Endobronchial Valve Implantation on Cardiac Function and Skeletal Muscle Function