Data will be abstracted through medical record review ensuring inclusion only of data from participants meeting all the inclusion criteria and none of the censoring criteria. Data will be collected retrospectively from study sites, including medical clinics, hospitals and academic medical centers.
Age
2–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Participants' medical records are eligible for abstraction only if all of the following criteria apply:
Confirmed diagnosis of PA based on diagnosis by molecular genetic testing (propionyl-CoA carboxylase subunitα\[PCCA\] and/or propionyl-CoA carboxylase subunitβ\[PCCB\] mutations).
Participant provided informed consent (and assent, as applicable).
Medical records with sufficient data to support medical encounter for CEC adjudication (MEA adjudication) must be available dating back to birth or 01 January 2015, whichever occurs later. Participants born prior to 2015 will require additional information to confirm eligibility.
Experienced at least one MDE in the 24 months preceding the Index Date or experienced at least 3 MDEs within any one 12-month retrospective review period (based on Index Date) dating back to birth or 01 January 2015, whichever occurs later.
Must have a confirmed age (months) of disease onset (early or late, where early is defined as the neonatal period).
Censoring Criteria:
Participants medical records meeting the following censoring criterion will not be abstracted:
Participation in a clinical study of any investigational agent.
Received gene therapy treatment
Confirmed organ transplantation
Investigator is no longer able to obtain relevant clinical information of the participant.
Death
You may not be if
\- Participation (prior or ongoing) in clinical study mRNA-3927-P101 (NCT04159103) or mRNA-3927-P101-EXT (NCT05130437).
