About Pricing FAQs Blog

Loading clinical trials...

Your health journey, clearly organized.

Find Clinical Trials →

Legal

Privacy Policy
Terms of Service

© 2026 Clareo Health. All rights reserved.

Back to clinical trial search

UNKNOWNNCT05768828

Stimulation-evoked Calcitonin Gene-Related Peptide (CGRP) as Biomarker of Migraine

This study aims to improve the management migraine by providing a more profound understanding of the interactions of pain disinhibition on the brain stem level and calcitonin gene-related peptide as a...

Lead sponsor: University Medicine Greifswald•1 locations•View source on ClinicalTrials.gov

Clareo plain-language summary

What this study is about

Generating AI summary...

Save this trial guide to your notes

Keep your clinical trial research organized — questions to ask, what to expect, and key details.

Sponsors

Lead Sponsor

University Medicine Greifswald

The study's focus is the investigation of mechanisms that are directly related to the pain generation in migraine. In this context, the primary endpoint is an enhancement of trigeminal stimulation evoked calcitonin gene-related peptide (CGRP). The stimulation is normalized using an established protocol to elicit the nociceptive blink reflex, which is a brain stem reflex to study the trigemino-spinal system. We expect CGRP levels to rise more in patients affected by migraine as compared to controls, based on the observation that painful stimulation elicits migraine attacks. Furthermore, baseline CGRP levels and their association with markers of brainstem excitability are probed.

Age

18 - 99 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Migraine according to ICHD-3 criteria (cases)
•No headaches or tension-type headache frequency \<1x/year (controls)

Exclusion Criteria

•other chronic pain disorder

Related studies

Chiropractic Care for Episodic Migraine

NCT06229834 · Episodic Migraine

Yogabased Movements for Primary Headaches (Migraine and/or Cluster Headache) - YOURHEAD

NCT07348783 · Cluster Headache - Episodic and Chronic, Migraine Headache, and more

Post-Marketing Study to Assess the Safety and Effectiveness of Oral Atogepant in Korean Adult Participants for the Prevention of Chronic or Episodic Migraine

NCT06603558 · Chronic Migraine, Episodic Migraine, and more

BE WELL With Migraine: Brain Education and WELLness With Migraine

NCT05987592 · Migraine

i-NEED: NEw migrainE Drugs Database

NCT07103694 · Episodic Migraine, Chronic Migraine, and more

View all related studies →

Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: March 14, 2023Terms

Trial snapshot

StatusUNKNOWN

Phase—

Enrollment20

Start dateFeb 2023

Last updatedMar 14, 2023

Condition

Locations shown

University Medicine Greifswald

Greifswald

For caregivers

Use Clareo to keep notes, questions, trial details, and next steps organized before and after appointments.

Start free trial →

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 14, 2023Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions