Allometric-Pace Study

Exclusion Criteria

• •Patients have or possible concomitant a diagnosis of heart failure, either reduced EF or preserved EF
• •Patients have persistent or chronic atrial fibrillation or clinically significant paroxysmal atrial fibrillation
• •Previously diagnosed with a history of organic heart disease: including congenital heart disease, coronary heart disease, old myocardial infarction, dilated cardiomyopathy, hypertrophic cardiomyopathy, cardiac amyloidosis, long QT syndrome, etc.
• •Patients have a known secondary cause of hypertension
• •Patients have hospitalization of a hypertensive emergency in the previous year
• •Patients have a history of renal disease or renal-artery diseases
• •Severe hepatic or renal dysfunction
• •Active acute infection
• •Patients cannot submit a signed informed consent form
• •Patients are pregnant or plan to be pregnant during study period
• •Patients participate in another study that will confound this study