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Diagnosing Variable Primary Aldosteronism. | Clinical Trials | Clareo Health

RECRUITING

Diagnosing Variable Primary Aldosteronism.

Do we Miss a Common Subset of Primary Aldosteronism in Which There is Cyclical or Exaggerated Diurnal Variation in Secretion?

NCT05765786•Queen Mary University of London

View on ClinicalTrials.gov

Summary

The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism.

Detailed Description

The main questions it aims to answer are: * Can we diagnose more people if we used 24 hour urine measurements? * In those with high amounts of aldosterone in their urine, is there a variable pattern to their aldosterone production? Participants will have a 24 hour urine measurement. They will also have multiple blood tests throughout the day to study the variability in aldosterone secretion.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•People with clinically suspected PA but have not met criteria for diagnosis. Suspicion based on low-renin (renin activity \<0.5 nmol/h/L or renin mass \<5 ng/L), plasma sodium \> 140mmol/L or plasma potassium \< 4mmol/L.
•Patients who have been diagnosed with PA and had previous aldosterone samples \<277 pmol/L, a level which would normally not qualify for confirmatory testing.
•Patients with aldosterone results done at different times that indicate variability in production.
•Willing to consent and participate in the study.

Exclusion Criteria

•Inability to withdraw β-adrenoceptor antagonist therapy for 2 weeks.
•People on end of life treatment.

Locations (1)

Queen Mary University of London

London, United Kingdom

Key Dates

Start Date

February 24, 2023

Primary Completion Date

February 24, 2026

Completion Date

February 24, 2026

Last Updated

June 8, 2025

Enrollment

100

ESTIMATED participants

Conditions

Primary AldosteronismHigh Blood Pressure

Contacts

Yun Ni Lee

CONTACT

+442078827275 y.n.lee@qmul.ac.uk

Tumi Kaminskas

CONTACT

+442078827275 research.governance@qmul.ac.uk

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 8, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Diagnosing Variable Primary Aldosteronism.

Inclusion Criteria

Exclusion Criteria

Randomised Trial Comparing Thermal Ablation With Adrenalectomy in the Treatment of Unilateral Asymmetric PA

68Ga-Pentixafor PET/CT Versus Adrenal Vein Sampling in Diagnosing Unilateral Subtype of Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion (PREDICT)

Prognosis of Primary Aldosteronism: A Prospective Cohort Study

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