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Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain | Clinical Trials | Clareo Health

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Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain

NCT05763758•Massachusetts General Hospital

Summary

This study aims to identify spatiotemporal alterations in thalamocortical circuitry functioning in both healthy subjects and patients with chronic pain, combining multimodal neuroimaging.

Detailed Description

Investigators will pursue this goal in both experimental and clinical models at two sites (Florida State U/FSU \& Mass General Hospital/MGH), implementing parallel enrollment of large and diverse samples (140 healthy participants and 60 patients with chronic low back pain/cLBP). Leveraging the fully developed multimodal neuroimaging methodology-simultaneous EEG-fMRI and combined EEG-MEG-fMRI, the investigators will investigate TC dysconnectivity (fMRI) and alpha dysrhythmia (EEG/MEG) during experimental pressure pain and chronic back pain.

Eligibility

Age

18 - 60 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Healthy subjects for both MGH and FSU sites
•1. healthy male and female adults
•2. Between the ages of 18 and 60 years
•3. Meeting the MRI / MEG / EEG screening criteria
•4. Fluent in English; English can be a second language provided that the patients understand all questions used in the assessment measures. This will be asked and judged during the phone screen.
•1. Volunteers 18-60 years of age
•2. Meet the Classification Criteria of the chronic LBP (having low back pain for more than 6 months)
•3. At least 4/10 clinical pain on the 0-10 LBP NRS
•4. Meeting the MRI / MEG / EEG screening criteria
•5. Fluent in English; English can be a second language provided that the patients understand all questions used in the assessment measures. This will be asked and judged during the phone screen.

Exclusion Criteria

•1. Current or past history of major medical, neurological, or psychiatric illness based on self-report
•2. History of cardiac, respiratory, or nervous system disease that, in the investigator's judgment, precludes participation in the study because of a heightened potential for adverse outcome (for example: asthma or claustrophobia)
•3. History of head trauma
•4. Pregnant or lactating
•5. Presence of any contraindications to MRI scanning (for example: cardiac pacemaker, metal implants, claustrophobia, pregnancy, cannot lie still in fMRI scanner)
•6. Conditions making study participation difficult (e.g., paralysis, psychoses, or other severe psychological problems as per the judgment of a study investigator during Session 1)
•7. Active substance abuse disorders (based on subject self-report)
•Subjects with chronic low back pain (MGH site)
•1. Specific causes of back pain (eg, cancer, fractures, spinal stenosis, infections)
•2. Complicated back problems (eg, prior back surgery, medicolegal issues)
+10 more criteria

Locations (2)

Florida State University

Tallahassee, Florida, United States

Massachusetts General Hospital

Charlestown, Massachusetts, United States

Key Dates

Start Date

May 1, 2023

Primary Completion Date

October 30, 2024

Completion Date

December 31, 2024

Last Updated

March 23, 2023

Enrollment

200

ESTIMATED participants

Conditions

Experimental PainLow Back Pain

Interventions

No intervention

OTHER

Contacts

Jian Kong

CONTACT

16179620978 jkong2@mgh.harvard.edu

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 23, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain

Inclusion Criteria

Exclusion Criteria

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