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COMPLETEDPHASE2

Prevention of Post-Operative Nausea and Vomiting With Propofol Infusion

NCT05759481•Milton S. Hershey Medical Center

Summary

The purpose of this study is to clarify whether or not a low-dose propofol infusion can effectively prevent postoperative nausea and vomiting (PONV) in patients who have a documented history of PONV and/or motion sickness.

Detailed Description

Propofol is administered as both low dose and as sole anesthetic in patients with history of PONV and/or motion sickness. But efficacy of one dose over the other is not studied. This study plans to clarify if propofol in low dose is as effective as its administration as sole anesthetic in patients with history of PONV and/or motion sickness

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Undergoing general anesthesia for elective surgery
•2. Documented history of Patient's self-disclosure of PONV and/or motion sickness during pre-anesthesia discussions
•3. No documented allergy/adverse reaction to propofol
•4. English speaking
•5. At least 18 years of age

Exclusion Criteria

•1. Any anti-nausea medication taken within 24 hours prior to surgery
•2. Unable to provide consent independently
•3. Allergy or adverse reaction to propofol
•4. Emergency surgery

Locations (1)

Penn State Health Milton S Hershey Medical Center

Hershey, Pennsylvania, United States

Key Dates

Start Date

February 1, 2024

Primary Completion Date

March 12, 2025

Completion Date

March 12, 2025

Last Updated

April 2, 2025

Enrollment

ACTUAL participants

Conditions

Post-operative Nausea and Vomiting

Interventions

Propofol

DRUG

Placebo

OTHER

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 2, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Prevention of Post-Operative Nausea and Vomiting With Propofol Infusion

Inclusion Criteria

Exclusion Criteria

Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery

Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy

A Study of Kytril (Granisetron) in the Prevention of Post-Operative Nausea and Vomiting (PONV) in Pediatric Subjects Undergoing Tonsillectomy or Adenotonsillectomy

Overnight Use of Electroacustimulation on Postoperative Nausea and Vomiting in the Outpatient Surgery Population

Single Dose Safety Study for Compound to Treat Post-Operative Nausea and Vomiting (PONV)