AKI stage 0 or stage 1 at the time of CKRT initiation.
Non-ATN AKI diagnosis. We intend on relying on local nephrology subspecialty expertise to reasonably exclude non-ATN diagnoses based on clinical suspicions combined with prespecified objective criteria. If there is a reasonable suspicion that the subject has non-ATN AKI based on this, they will be excluded from the trial.
Acute coronary syndromes, acute stroke, or acute major vascular compromise requiring medical or surgical interventions within 48 hours of randomization.
Active hemorrhage requiring blood transfusions at the time of screening.
Acute on Chronic Liver Failure.
Suspicion of hepato-renal syndrome.
Presence of any solid organ transplant at any time prior to admission.
Severe burns with a modified Baux score \> 100 (%TBSA+Age+17 for Inhalation Injury).
Bone marrow transplant within the last year.
Chronic immunosuppression with an average of \>20 mg/day of prednisone or other steroid sparing immunosuppressants for the past 30 days prior to hospital admission.
Individuals who have a history of primary or secondary immune disorders including, but not limited to, HIV or AIDS.
Dry weight of \>150kg.
Platelet count \<15,000/mm3.
Patient is a prisoner or member of a vulnerable population.
Patient is pregnant or breast feeding.
Concurrent enrollment in another interventional clinical trial for an investigational drug or device.
