Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
NYU Langone Health
With
American Society of Clinical Psychopharmacology
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Provide written informed consent, as approved by the NYU Institutional Research Ethic Board (IRB).
Patients ages 18-65;
Current/acute Major Depressive Disorder (MDD) diagnosis, per MINI psychiatric interview;
At least moderate severity of depression (Montgomery-Åsberg Depression Rating Scale (MADRS) score of at least 20 at initial screen);
You may not be if
DSM-5 diagnosis of Bipolar disorders, Cyclothymia, Schizoaffective disorder, Schizophrenia; any psychotic disorder or affective psychosis;
Subjects that have had more than two failures of adequate anti-depressant trials in the current MDD episode;
Subjects on psychotropic medications other than SSRIs, NDRIs, SNRIs, or mirtazapine (occasional use of sleep agents, equivalent to lorazepam 1 mg or zolpidem 10 mg, will be allowed);
Those that have previously been on SGLT2 inhibitors;
A significant history of non-adherence to treatments;
History of neurologic / seizure disorder;
A significant history of non-adherence to treatments;
History of dementia/cognitive dysfunction (MOCA \< 22);
A primary diagnosis of a personality disorder, in the opinion of the screening clinician;
DSM-5 substance use disorder (drug/alcohol) active within the past 12 months, or positive urine toxicology at screening;
History of diabetic ketoacidosis;
History of recurrent genital mycotic infection;
GFR \<45;
HgA1c.\>8.0%
History of an allergic reaction to an SGLT2 inhibitor.
Pregnancy or lactation (women of reproductive age, ie \<50 years old, should be on licensed hormonal or barrier method contraception).
Any known pancreatic disease resulting in insulin deficiency (T1D, history of pancreatitis, pancreatic surgery);
History of liver or kidney disease;
Hypersensitivity to empagliflozin or any of the excipients in JARDIANCE.
Clareo Health | Sodium-Glucose Cotransporter-2 Inhibitor (SGLT2) in Major Depressive Disorder (MDD)
