Finding studies
Finding studies
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Lead
AstraZeneca
This is a Phase I, single dose, non-randomised, open-label, parallel group study to examine the PK, safety, and tolerability of mitiperstat in participants with hepatic impairment and participants with normal hepatic function. Participants will be assigned to one of the following cohorts as per Child-Pugh classification: * Cohort 1: Eight participants with Mild hepatic impairment (Child-Pugh A) * Cohort 2: Eight participants with Moderate hepatic impairment (Child-Pugh B) * Cohort 3: Six to eight participants with Severe hepatic impairment (Child-Pugh C) * Cohort 4: Eight to twelve participants with Normal hepatic function A final safety follow-up visit on Day 21 will be there after all procedures are completed on Day 15.
Age
18–85
Sex
ALL
Healthy volunteers
Not accepted
