Oxidative Skeletal Muscle Metabolism in Chronic Heart Failure Patients With and Without Iron Deficiency

Inclusion Criteria

• •For HFrEF patients:
• •Diagnosis of chronic HF of either ischemic or non-ischemic etiology;
• •Stable, evidence-based medical therapy for HF;
• •LVEF \<40% measured \<5 year prior to inclusion;
• •NYHA class II - III (symptomatic HF) at moment of inclusion;
• •For HFpEF patients:
• •Diagnosis of chronic HF of either ischemic or non-ischemic etiology;
• •LVEF \>40% and one of the following parameters, measured \<5 year prior to inclusion;
• •Left atrial volume index (LAVI) \>34 mL/m2 or
• •left ventricular mass index ≥115 g/m2 (for males) or ≥95 g/m2 (for females) or
• •E/e' ≥13 or
• •mean e' (septal and lateral) \<9 cm/s
• •NYHA class II - III (symptomatic HF) at moment of inclusion;
• •Serum NT-proBNP ≥125 pg/mL when in sinus rhythm; \>300 pg/mL when in atrial fibrillation.
• •Additional inclusion criterion for subjects with ID:
• •\- Iron deficiency, defined as TSAT \<20%.