Safety and Efficacy of Allogenic NK Cells in Combination With Chemotherapy in the Treatment of r/r AML After Allo-HSCT

Exclusion Criteria

• •1. Confirmed APL;
• •2. ≥2 grade persistent nonhematologic toxicity of associated with prior treatment;
• •3. Patients with grade II-IV graft-versus-host disease (GVHD) requiring the use of immunosuppressive agents ;
• •4. Systemic steroid therapy exceeding the equivalent of ≥30mg/kg/day of prednisone within 48 hours prior to the first dose of study drug or other immunosuppressive therapies (except for topical and inhaled glucocorticoid therapy, or short-term prophylactic therapy with glucocorticoid) ;
• •5. Severe cardiovascular and cerebrovascular diseases, including: (1) Some cardiovascular and cerebrovascular diseases (such as congestive heart failure, acute myocardial infarction, unstable angina pectoris, stroke, transient ischemic attack, deep vein thrombosis or pulmonary embolism, etc.) occur within 6 months prior to the first dose of study drug; (2)New York Heart Association (NYHA) Class ≥3 or uncontrolled malignant arrhythmias; (3)The researchers assessed that the subjects with other cardiovascular and cerebrovascular diseases are not suitable for the study;
• •6. Any active infection requiring systemic therapy by intravenous infusion within 14 days prior to the first dose of study drug, including: hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), syphilis infection, or active pulmonary tuberculosis;
• •7. History of hypersensitivity reactions to murine protein-containing products, or macromolecular biopharmaceuticals such as antibodies or cytokines;
• •8. Previous or next organ transplant (except for HCT);
• •9. Women who are pregnant (urine/blood pregnancy test positive) or lactating;
• •10. Patients cannot guarantee effective contraception (condom or contraceptives, etc.) within 6 months after enrollment;
• •11. Any unstable condition potentially imperiling patient safety and compliance;
• •12. Known alcohol dependence or drug dependence;
• •13. According to the investigator's judgment, the patient has other unsuitable grouping conditions.