Comparative Efficacy of Novel Transcranial Random Noise Stimulation Versus Direct Current Stimulation on Augmenting Digital Mirror Therapy in Chronic Stroke

Lead Sponsor

Chang Gung Memorial Hospital

Age

35 - 85 years

Sex

ALL

Healthy Volunteers

No

•1. 3 months onset from a first-ever unilateral stroke;
•2. an initial FMA scores between 18 to 56, indicating moderate to mild upper extremity motor impairment55;
•3. age between 35 to 85;
•4. no excessive spasticity in any of the joints of the affected arm (shoulder, elbow, wrist and fingers);
•5. ability to follow instructions and perform tasks (Mini Mental State Examination scores 24);
•6. no participation in any neurorehabilitation experiments or drug clinical trials
•7. willing to provide written informed consent

•1. contradiction to tRNS and tDCS including a history of epilepsy, pregnant, having pacemakers and metallic implants in the neck and head ;
•2. History of drug or alcohol abuse ;
•3. concomitant neurological conditions such as dementia, Parkinson's disease, brain tumor, brain injury and other brain diseases (such as intracranial hypertension or cerebral edema);
•4. Botulinum toxin injections 3 months before enrollment
•5. have unstable cardiovascular status such as uncontrolled hypertension or New York Heart Association (NYHA) Class III/IV heart failure or are not suitable for receiving tRNS by the physician's assessments.

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