A First Study in Healthy Volunteers of a New Mobile Phone Application Measuring the Eyes Before and After Medication

Exclusion Criteria

• •Participating in another clinical investigation which may affect the study outcome according to clinical judgement
• •Pregnancy or Lactating
• •Blind
• •Deaf
• •Abnormal ECG (QTc time \>450 ms) at enrollment
• •Current or recent history of alcohol misuse assessed by AUDIT where ≥6 points for women or ≥8 points for men indicates a potential misuse
• •Current or history of psychiatric disorder or drug misuse assessed by M.I.N.I where the outcome will be based on clinical judgement
• •Any disease or condition that may influence pupillary reflexes based on clinical judgement
• •Undergone eye surgery that may influence pupillary reflexes based on clinical judgement
• •Ongoing treatment with medications which may interfere with eye measurements based on clinical judgement
• •Ongoing treatment with medications which may interfere with any of the medicinal products to be used
• •History or presence of allergy or serious reaction to the medicinal products to be used
• •History or presence of cardiovascular disease, e.g., arteriosclerosis, hypertension, or cor pulmonale
• •History or presence of sleep-related breath disorder
• •History or presence of gastrointestinal disease, e.g., paralytic ileus, acute abdomen, delayed gastric emptying, or chronic constipation
• •History or presence of pulmonary disease, e.g., acute pulmonary insufficiency, severe respiratory depression with hypoxia, chronic obstructive lung disease, or bronchial asthma
• •History or presence of autoimmune neuromuscular disease, e.g., myasthenia gravis
• •Not able to read or understand the local language
• •Any other condition that as judged by the investigator may make the follow-up or investigation inappropriate
• •That according to the Declaration of Helsinki is deemed unsuitable for study enrollment