Effect of Pharmacological Interventions on Systolic Blood Pressure Drops (SynABPM 2 Proof-of-concept)

Inclusion Criteria

• •Eligible patients were those who fulfilled all the following criteria:
• •had received a diagnosis of reflex syncope
• •had undergone an ABPM as part of the routine work-up of syncope in use in these hospitals that had shown one or more daytime SBP drop \<90 mmHg or one or more daytime drops \<100 mmHg in patients with average 24-hour SBP ≥125 mmHg
• •had received instructions in order to abolish/reduce their antihypertensive therapy with the aim to prevent syncopal recurrences or had received active drug therapy, i.e., fludrocortisone, in order to increase their arterial blood pressure.
• •had performed a second ABPM within 6 months from ABPM 1 in order to verify the effect of the prescribed change in therapy