Prevalence and Development of Liver Dysfunction in Hematopoietic Stem Cell Transplant

Study Description: Liver dysfunction is common in patients that have undergone hematopoietic stem cell transplant (HSCT) and is associated with increased mortality. We aim to study the natural history of liver dysfunction in HSCT, what factors contribute to the development of liver dysfunction, and how underlying liver disease affects complications and outcomes of HSCT. We hypothesize that those patients with underlying liver disease or those who develop liver disease have increased morbidity and mortality compared to those without liver disease. Objectives: Primary Objective: To determine whether, at 3 months (Visit 7) after transplant, patients with liver disease at transplant are more likely to have died or have a total bilirubin \>=4 mg/dL than those without liver disease at transplant. Secondary Objectives: To understand the impact of liver disease in HSCT on morbidity/mortality. To understand the development and progression of liver disease in hematopoietic stem cell transplant Tertiary Objectives: To identify predictive/protective factors associated with presence or absence of liver disease, and severity of liver disease in patients receiving hematopoietic stem cell transplant. Endpoints: Primary Endpoints: * Death or total bilirubin \>=4 mg/dL at 3 months (Visit 7) after the transplant * Mortality rate Secondary Endpoints: * Morbidity/cause of death * Development of portal hypertension and sequelae (i.e., ascites, variceal bleed, thrombocytopenia, elevated portal pressure) * Development of liver failure (i.e., coagulopathy with an International Normalized Ration (INR) 1.5, and any degree of mental alteration (encephalopathy in a subject without preexisting cirrhosis and with an illness of \< 26 weeks duration, including subjects with Wilson s disease, vertically acquired HBV, or autoimmune hepatitis per AASLD guidelines 2011) * Rate of infection (type bacterial, viral fungal, location: central line, organ infection, sepsis, etc.) Liver dysfunction, characterized by development of the following conditions: * Synthetic dysfunction: Total bilirubin \> 4 mg/dL (20-40% in HSCT recipients or INR \> 1.5 * Portal hypertension: Presence/absence of any of the following will qualify as portal hypertension- ascites, collateral vessels, elevated portal pressure * Liver injury: ALT\>4 times the upper limit of normal (22 IU/L in women, 29 IU/L in men) or Alkaline phosphatase \>2.5 times the upper limit of normal Tertiary Endpoints: * Imaging, laboratory analysis of liver dysfunction, liver tissue pathology, medications/treatment course will be reviewed. * Tertiary studies include stool microbiome studies, metabolomics, microbial translocation markers, flow cytometry, transcriptomics, growth factor measurement, cytokines, and chemokines measurement.