Effects of Administration of SCFA in Rheumatoid Arthritis Inadequate Responders

Exclusion Criteria

• •1. Participants who are pregnant or are currently breastfeeding
• •2. History of sensitivity to study compound or any of their excipients
• •3. Previous intolerance to SCFA or related compounds
• •4. Current antibiotic treatment (within 3 months of screening) at discretion of PI
• •5. Current consumption of probiotics (within 3 months of screening) at discretion of PI
• •6. Severe hepatic impairment (eg, ascites and/or clinical signs of coagulopathy)
• •7. Renal failure (eGFR \<30 or requiring dialysis) by history
• •8. History of other autoimmune disease at discretion of PI
• •9. Current immunodeficiency state (e.g., cancer, HIV, others)